Efficacy of Intracameral moxifloxacin in Cataract surgery to prevent post-operative Endophthalmitis

To establish the efficacy of intracameral injection of moxifloxacin 0.5% [0.5 mg/ml or 500 micro g] ophthalmic solution in patients having routine cataract surgery as prophylaxis to endophthalmitis. Department of Ophthalmology, Sindh Government Qatar Hospital Orangi Town, Karachi. Prospective Case Series. A prospective study was conducted from the period of February 2009 to November 2009 in department of ophthalmology Sindh Government Qatar Hospital Orangi Town, Karachi. Total 530 patients were treated with intracameral injection of 0.5% moxifloxacin solution in 0.1 [500 micro g] ml dose at the conclusion of the surgery with IOL implantation either by doing phacoemulsification or conventional method. Safety parameters included VA, IOP, corneal clarity and edema, aqueous cells and flare were evaluated preoperatively and postoperatively for 3 months in patients who received intracameral injection. Five hundred eyes completed the study while 30 patients were excluded from the study because of poor follow up. Aqueous cells and count on first and third postoperative days were insignificant in all patients who were given intracameral injection of moxifloxacin at the last step of surgery. All eyes had a postoperative best corrected visual acuity of 20/30 or better. No stromal edema was observed. No drug related adverse effects were reported. No case of endophthalmitis was reported during and after the 3 months follows up period. Intracameral injection of moxifloxacin 0.5% [0.5mg/ml or 500 micro g] ophthalmic solution appears to be nontoxic in terms of visual rehabilitation, anterior chamber reaction and corneal edema. It is found very effective for the prophylaxis of endophthalmitis at the conclusion of routine cataract surgery

Role of trabeculectomy in the management of hypertensive traumatic total hyphaema

To assess the visual outcome and complications after trabeculectomy in patients of hypertensive traumatic total hyphaema. Case series. Department of Ophthalmology, Dow University of Health Sciences, Karachi, from June 2004 to May 2008. Patients with total hyphaema admitted in eye ward were included. Socio-demographic data was recorded. Complete ophthalmic examination and B-scan ultrasonography were undertaken. Trabeculectomy was performed. Visual outcome, intraocular pressure reduction and complications were recorded. Descriptive statistics were calculated. Twenty two patients underwent trabeculectomy with mean age was 23.18 +/- 12.67 years. Male to female ratio was 3.26:1. Toy gun pellet injury was present in 6 [27.3%] cases. The average intraocular pressure before surgery was 40.86 mm of Hg. All the patients had a visual acuity of light perception with an accurate projection. Evidence of corneal blood staining was observed in 16 [72.7%] patients. Mean intraocular pressure at last follow-up was 15.1 +/- 2.11 mm of Hg with a minimum of 12 mm and maximum of 20 mm of Hg in 19 [86.3%] patients [complete success]. Three patients were on additional anti-glaucoma medications. Filtering bleb was functional in only 4 [18.2%] patients. Visual acuity was 6/18 or better in 18 [81.8%] patients at last follow-up. Trabeculectomy was a satisfactory procedure for traumatic hyphaema for restoring good vision, if undertaken earlier. This procedure is not associated with significant complications and is very useful in reducing raised intraocular pressure

Role of fundus fluorescein angiography in the diagnosis of central serous chorioretinopathy

This study was carried out in the Department of Ophthalmology, Dow Medical College and Civil Hospital, Karachi, to ascertain the role of Fundus Fluorescein Angiography [FFA] in the diagnosis of Central Serous Chorioretinopathy [CSCR] and to see the various patterns of CSCR on FFA. In the outpatient department 33 patients were diagnosed as having CSCR on the basis of careful history taking and thorough clinical examination. They included 28 [84.85%] males and 5 [15.15%] females with a sex incidence of 6 Male.- 1Female. Majority of cases i.e. 28[84.85%] were between 20-40 years of age, whereas only 3[9.09%] were in the late teens and 2[6.06%] above the age of 40 years. Right eye was involved in 15 [45.45%] and left eye in 18 [54.55%] cases. The presenting clinical features were blurred vision, micropsia, metamorphopsia and positive central scotoma. At the time of presentation a visual acuity of 6/12 or better was seen in 25 [75.75%] cases, and 6/18 or less in 8 [24.25%] cases. FFA showed 21[63.64%]cases with ink-blot and 11[33.33%] with smoke-stack pattern, whereas one [3.03 %] case turned out as Sub-Retinal Neovascular Membrane [SRNVM]